It was reported that intra‐tumoral aromatase was expressed in approximately 80% of LGESS13 and 60% of uLMS.7 AIs not only reduce the level of estrogen in the circulation by inhibiting the activity of aromatase in peripheral tissues, but also inhibit the biosynthesis process of estrogen within tumor tissues.14 Based on the molecular structures and mode of action, AIs are divided into two types: steroidal AIs and non‐steroidal AIs. This evidence concerns the gene CYP19A1 and neoplasm.