Until now, RP susceptibility loci were identified in DNA repair–related, inflammation–related, angiogenesis–related and stress response–related pathways with different underlying mechanisms.32 SP‐D, a surfactant proteins known for its contribution to the host's lung immunity,39 has been mentioned to be biomarker of severe RP after radiotherapy.40 This study expanded the range of RP candidate genes to a new gene encoded pulmonary surfactant protein D, suggesting another mechanism may underlying the pathogenesis of RP. This evidence concerns the gene SFTPD and retinitis pigmentosa 1.