In the present study, three tagSNPs (rs1998374, rs911887, rs2255326) were significantly associated with grade ≥2 RP and haplotype (T‐A‐C) in SP‐D was significantly associated with both grade ≥2 RP and grade ≥3 RP in lung cancer patients treated with radiotherapy. This evidence concerns the gene SFTPD and lung carcinoma.