Several studies have previously described the α7nAChR as a critical receptor involved in the anti‐inflammatory effect of the VN.7, 17, 18, 19 Of interest, agonists of the α7nAChR, nicotine and GTS‐21, were recently shown to have anti‐inflammatory properties in a murine food allergy model.20 Surprisingly, we failed to support a critical role for the α7nAChR in our observed therapeutic effect of VNS. The gene discussed is CHRNA7; the disease is food allergy.