In fact, many other pathogenic mechanisms such as disruption in autophagy [72], aberrant ubiquitin-proteasome activity [73], protein aggregations [46,74], aberrant transcription [75], impaired TrkB postsynaptic signaling [76], impaired vesicular transport [77], impaired calcium trafficking [78], aberrant metabolism [79], mitochondrial dysfunction [80], heightened inflammatorily response [81], and inhibition of TEAD/TAP [82] are all been reported in HD. Here, NTRK2 is linked to Huntington disease.