CCR2 and cryptococcosis: In this study, we sought to clarify the role of IM and their derivatives in a murine model of acute cryptococcosis using a highly virulent serotype A strain of C. neoformans. We utilized CCR2-DTR depleter mice [5] and a new constitutive CCR2-Cre mouse model to probe the functional role of IM in C. neoformans control and host survival.