Data indicate that genetic mutations of cardiac developmental genes such as NKX2-5, SMAD3, NTRK3, GATA6, TBX2, TBX18, ATA6, and TBX2, unique copy number variations [6], and chromosomal aneuploidy such as trisomy 13, 18, or 21 can play an important role in the etiology of VSD [7]. This evidence concerns the gene TBX2 and ventricular septal defect.