Noteworthy, circulating concentrations of GDF11 were unchanged regarding glycemic status [LN-NG (n=40) 0.138 ± 0.183, OB-NG (n=93) 0.128 ± 0.136, OB-IGT (n=46) 0.145 ± 0.276, OB-T2D (n=47) 0.162 ± 0.251 ng/mL; P=0.834] as depicted in Figure 3C. The gene discussed is GDF11; the disease is type 2 diabetes mellitus.