For example, in patients who experience post-operative AF, SERCA2 is significantly decreased in the atrial tissue (Zaman et al., 2016), but those with PLN mutations have decreased AF susceptibility in the context of arrhythmogenic right ventricular cardiomyopathy (Bourfiss et al., 2016). This evidence concerns the gene ATP2A2 and arrhythmogenic right ventricular cardiomyopathy.