AKT1 and cancer: Luckily, the mechanism of how it works was recently unraveled by Zhu et al., they found out that GLA inhibited five-zinc finger Glis (GLl 1) via regulating phosphatidylinositol 3 kinase/protein kinase B (P13K/Akt) signaling pathway thus induced apoptosis of these cancer cells (Zhu et al., 2018).