USP33 and gastric cancer: To assess the overall frequency of genetic alterations of USP33 in GC patients, we analysed large datasets from cBioPortal for Cancer Genomics (http://cbioportal.org).29 As shown in Figure 3J, mutations of the USP33 gene in GC patients were detected in five independent cohorts, ranging from 1% to 4.55%, while copy number alteration (CNA) was observed in three cohorts.