NIPA2 and temporal lobe epilepsy: An increase in BK channel currents usually leads to absence epilepsy,37, 38 and a decrease in BK channel currents may be associated with temporal lobe epilepsy.23 However, we identified NIPA2 loss‐of‐function mutations from patients with CAE, and NIPA2 dysfunction can decrease BK channel currents to obtain neuronal hyperexcitability.