HES1 and cancer: Previous reports have indicated the significant role of Notch1 signalling in hepatic oncogenesis.24, 25 Recent work has also implicated the activation of Notch1 signalling in CT antigen‐mediated cancer progression.28 As shown in Figure 7A, KK‐LC‐1 knockdown greatly attenuated the expression of NICD1 and Notch1 effector Hes1 in HCCLM3 cells, and KK‐LC‐1 overexpression significantly enhanced the activity of Notch1 signalling in Huh7 cells.