NOTCH1 and hereditary clear cell renal cell carcinoma: In breast cancer, JAG1 activates Notch signalling and promotes tumour metastasis.13 Inhibition of Notch1/2 could suppress cell proliferation in renal cell carcinoma.14 Notch1 overexpression leads to enhanced tumour growth in melanoma.15 Notch signalling has been reported to be activated in HCC and promotes liver tumour formation.16 Upon ligand binding, Notch undergoes a series of cleavage events to generate its activated form NICD.