Presenilin‐1 promotes cell proliferation in HCC.29 Presenilin‐1‐dependent γ‐secretase is a crucial proteinase for Notch1 activation.40 γ‐secretase is a complex comprising Presenilin, anterior pharynx‐defective 1, nicastrin and Presenilin enhancer‐2. The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.