To date, only five germline variants of CDH1 were described in gastric cancer patients in South America: 4 in Brazil [8–10] (c.185G>T, c.1018A>G, c.1763_1764delTG, c.1023T>G), 1 in Argentina [11] (c.1913G>A), and 1 in Colombia [6] (c.2245C>T). The gene discussed is CDH1; the disease is gastric cancer.