NRSN1 and neoplasm: Furthermore, a directional change was also found between day 1 and day 7 for TGFB1, NGFRAP1 (involved in the extrinsic apoptotic signaling pathway [33]), MGST1, LY6H (involved in tissue morphogenesis), and NRSN1. TGFβ is an oncostatic regulator which, if mutated, is central in tumor cell proliferation, angiogenesis, and invasiveness.