The generation of a suppressive environment by CMV may be one method that the virus uses to modulate its environment to persist in myeloid lineage cells [4], certainly we have shown that latent infection of CD34 + cells results in the production of cellular IL-10 alongside the HCMV homolog vIL-10 (UL111a) and that these secretomes inhibit T cell effector function [21]. The gene discussed is IL10; the disease is disease arising from reactivation of latent virus.