Specifically, aloe-emodin's anti-cancer properties in vitroemanate mainly from cell death induction and an-ti-proliferative processes that entail (a) increased levels of pro-apoptotic caspases, cytochrome c, p53 and p21, BAX, and free radicals, and decreased levels of anti-apoptotic BCL-2 and DNA repair enzymes; (b) decreased cyclin A, CDK2, VEGF, and NF-KP levels; (c) cell cycle arrest in the S and G2/M phase; and (d) decreased MMP levels and migration. Here, CCNA2 is linked to cancer.