The Rocket AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) excluded those patients taking aspirin in combination with thienopyridines within five days prior to randomization; however, 109 patients in VKA group (1.55%) and 143 patients in rivaroxaban group (2.03%) took triple therapy. The gene discussed is F10; the disease is stroke disorder.