Loss-of-function mutations in PTPN11 [encoding protein tyrosine phosphatase Src homology domain-2 containing tyrosine phosphatase [SHP2]] have been implicated in hypertrophic cardiomyopathy associated with Noonan syndrome, and endothelial-specific expression of SHP2 was sufficient to induce adult-onset cardiac hypertrophy in mice (217). This evidence concerns the gene PTPN11 and Adult onset.