TP53 and myocardial infarction: Previous studies had shown that global p53 deficiency (45, 235, 236) or pharmacological p53 inhibition (237) protect against cardiac injury, whereas activation of p53 following deletion of the p53 inhibitor mdm2 in cardiomyocytes accelerated left ventricular function deterioration in response to aortic banding or myocardial infarction (238).