CCND2 and persistent truncus arteriosus: Direct comparisons revealed that cardiac hypertrophy experimentally induced by transverse aortic constriction (TAC) resulting in chronically increased pressure overload was associated with a reduced capillary density, whereas capillary angiogenesis was maintained in hearts exposed to volume overload induced by aortocaval shunt (51, 52) or cardiomyocyte hyperplasia induced by genetic overexpression of cyclin D2 (53).