PTPA and heart disorder: Based on the central role of the PP2A family in the regulation of crucial cellular processes, it comes to no surprise that PP2A dysfunction is associated with human diseases, including neurodegenerative disorders (Sontag and Sontag, 2014), heart disease, diabetes (Baskaran and Velmurugan, 2018), asthma (Kobayashi et al., 2011), and cancer (Seshacharyulu et al., 2013; Thompson and Williams, 2018).