IDH1 and infection: Two additional enzymes were found in reduced abundance under both infection conditions, isocitrate dehydrogenase 1 (IDH1, O75874) that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (in the cytoplasm), and malate dehydrogenase 1 (MDH1, P40925) that catalyzes the reversible cytoplasmic conversion of oxaloacetate to malate.