In other examples, curcumin, has been loaded into EL-4 lymphoma cell-derived exosomes and delivered to activated myeloid cells, for protection against LPS-induced inflammation in mice (288), and intra-nasal exosomal delivery of curcumin, or a signal transducer and activator of transcription-3 (STAT3) inhibitor JSI124, has been shown to cross the blood-brain-barrier and suppress GL26 brain tumors in a syngeneic C57BL mouse model of brain cancer (193). Here, STAT3 is linked to brain neoplasm.