TNFSF10 and neoplasm: So too, EVs carrying death-inducing cytotoxic cytokines TNF, TNF-related apoptosis-inducing ligand, TRAIL, and Fas ligand (FasL) induces apoptosis of tumor-specific T cells (210), and exosomal EVs block NKG2D to inhibit NK cell activation and NK tumoricidal activity (211–213).