Gastric cancer-derived exosomes stimulate the proliferation of other recipient gastric cancer cells, at least in part, through the activation of the PI3K/Akt and MAPK/ERK kinase pathways (185), and exosomes mediate the disposal of a tumor suppressor miRNA miR-23b that aids in the dissemination of cancer cell metastasis (247). This evidence concerns the gene AKT1 and neoplasm.