To determine whether immune checkpoint blockade can enhance the response to radiation, Demaria et al. utilized the 4T1 mouse mammary model and treated mice with either a monoclonal antibody against CTLA-4 (9H10) alone, RT (24 Gy in 1 or 2 fractions) to the primary tumor alone, or RT in combination with 9H10. This evidence concerns the gene CTLA4 and neoplasm.