In fact, since 2016, the CNS WHO divided GBM in 2 main groups (1) IDH-wildtype (about 90 % of cases), which corresponds most frequently to de novo GBM and predominates in patients over 55 years of age, and (2) IDH-mutant (about 10 % of cases), corresponding to secondary Glioblastoma arising from lower grade diffuse glioma and preferentially arises in younger patients (1). Here, IDH2 is linked to glioblastoma.