Notably, GSCs have a lower immunogenicity and a higher suppressive activity compared to non-GSCs GBM cells, through several mechanisms: the inhibition of T cells proliferation (56), the proliferation of regulatory T cells (57) and the recruitment of myeloid-derived suppressor cells (MDSCs), via the secretion of macrophage migration inhibitory factor (MIF) or exosomes (58, 59). The gene discussed is MIF; the disease is glioblastoma.