INS and type 1 diabetes mellitus: A previous study of internal structure of lens performed with corrected Scheimpflug imaging by Wiemer et al. [9] found that the lens was consisted of three cortical zones and the nucleus; in T1DM patients, all four layers rather than one typical layer of the lens were significantly thicker compared with those of the healthy control subjects, which supports the hypothesis that the thickening of the lens is the result of cellular or extracellular overhydration rather than insulin-induced mitogenesis of the epithelial cells.