Higher percentages of overhydration (OH >1L) and lower serum albumin levels [<40g/L (<4g/dL)] were also seen in advanced CKD: more subjects in stage 5 CKD had fluid overload than those in stage 3 and 2 CKD (p<0.001, and p=0.01, respectively), and lower serum albumin versus stage 3 CKD (p=0.02). The gene discussed is ALB; the disease is Hypervolemia.