Furthermore, given that adiponectin sensitivity, mediated by adiponectin/adiponectin receptors signaling, plays a significant role in the pathogenesis of NAFLD [18], we performed western blot analysis of adiponectin, AdipoR1, and AdipoR2 in adiponectin target liver tissue. The gene discussed is ADIPOR1; the disease is metabolic dysfunction-associated steatotic liver disease.