The catechol-o-methyltransferase (COMT) genotype influences brain functional (including auditory processing, which is highly related to AVHs) and dopaminergic alterations both in healthy people and in patients with schizophrenia (Lu et al., 2007; Kang et al., 2010; Gothelf et al., 2011; Edgar et al., 2012; Tian et al., 2013a,b; Li et al., 2015; Steiner et al., 2018) and the efficacy of dopamine antagonists in patients with schizophrenia (Olgiati et al., 2009; Sagud et al., 2010; Huang et al., 2016). Here, COMT is linked to schizophrenia.