ACKR2 prevents tumor growth also when it is expressed by Kaposi's sarcoma cells where it is down-regulated by the oncogenic pathway KRAS/BRAF/MEK/MAPK (123), while in anaplastic thyroid carcinomas ACKR2 expression is downregulated by miR-146a (124). Here, ACKR2 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.