The levels of cylindromatosis protein (CYLD) (Figures 6A,B), p-TAK (Figures 6A,C) and p-P38 (Figures 6A,E), and the ratios of p-TAK/TAK (Figure 6D) and p-P38/P38 (Figure 6F) in the colonic mucosa of rats with untreated colitis were higher than those in the normal control rats. Here, CYLD is linked to colitis.