In TNBS-induced colitis, cytokine imbalance was demonstrated by high expression of proinflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-17) and low expression of anti-inflammatory cytokines (IL-4 and IL-10) to induce inflammatory damage to the colonic mucosa. The gene discussed is IFNG; the disease is colitis.