A positive correlation between brain ß-arrestin (ß-arrestin1 and 2) levels (both protein and mRNA) and Alzheimer’s disease diagnosis, severity, and amyloid burden has been demonstrated by several investigators (Liu et al., 2011; Thathiah et al., 2012; Liu et al., 2013). This evidence concerns the gene SAG and early-onset autosomal dominant Alzheimer disease.