EPO and hypersplenism: Various mechanisms of malarial anaemia have been investigated including increased RBC destruction through rupture of parasitized red blood cells (PRBCs) [27], phagocytosis of PRBCs [28], hypersplenism [29], and hapten-induced intravascular haemolysis [30] as well as decreased RBC production through inflammation-induced erythroid hypoplasia [31], imbalance of cytokines [32]m and suppression of erythropoietin synthesis [33].