APC and cancer: Genetic research has mainly focused on single factors such as MSI status and known cancer genes, including APC, KRAS, and BRAF, with varying results.8,13–15 Thus far, there has been only a few exome-wide studies on SCRC and one study including whole-genome sequencing data of a SCRC case.16–19 In general, these studies have supported the idea of independent origins of synchronous tumours.