TP53 and neoplasm: In a previous study by the Ogino group in which a survival analysis was conducted in patients with stage I, II, III, or IV CRC according to p53 expression status ( < vs. ≥ 50% of tumour cells with nuclear staining), p53-positivity ( ≥ 50% of tumour cells with nuclear staining) was associated with poor prognosis in the multivariate analysis.