These included the DNA helicase and chromatin remodeling factor CHD8, which silences β-catenin mediated transcription23, Pontin52 (also known as TIP49), a c-Myc interacting protein involved in chromatin remodeling and transcription24, APC, a tumor suppressor and antagonist of the Wnt signaling pathway18, PP2A, a phosphatase that regulates Wnt signaling at several levels25, and CtBP1 (C-terminal binding protein1), a repressor of Wnt signaling that associates with LSD126 (Fig. 2a, Supplementary Fig 1c). The gene discussed is CHD8; the disease is neoplasm.