In addition, a corresponding augmented expression of Chop, and a higher frequency of Chop+ cells, were noticed in CD8+ TILs from mice bearing B16 melanoma or 3LL lung carcinoma cells, as well as in ascites-related CD8+ T cells from ID8-Defb29/Vegf-a ovarian tumors31,32, compared to splenic CD8+ T cells from the same mice (Fig. 1b, Supplementary Fig. 1a, b). This evidence concerns the gene VEGFA and melanoma.