In addition, specific non-subjective analysis focusing on T cells showed higher levels of nuclear and cytosolic CHOP in tumor-related CD8+ T cells, compared to those from healthy ovary tissues (Fig. 1e, f, Supplementary Fig. 2a, c, d), suggesting the driving effect of the TME in the induction of CD8+ T cell CHOP. The gene discussed is DDIT3; the disease is neoplasm.