As shown in Fig. 1f, CD163 expression was positively associated with VCAM-1 expression in colon adenocarcinoma, and the IHC analysis and quantification in clinical specimen also showed the positive correlation between CD206 and VCAM-1 expression (Fig. 1g), which showed TAM infiltration in VCAM-1 overexpression CRC tissue was higher compared with VCAM-1 low expression CRC tissue or normal tissue. This evidence concerns the gene MRC1 and colon adenocarcinoma.