As per our results suggested that all the above-mentioned cascade signaling G protein pathway genes, phospholipase C gene, protein kinase C gene, ion channel genes: GNA15, GNAO1, GNG3, GNG4, GNGT1, GNGT2, GRK4, GRK7, GPSM2, RGS3, PLCB2, PIK3CG, PTK2, PRKCZ, CACNA1A, CACNA1B, CACNA1E, and KCNJ9 are significantly upregulated in AMD conditions when compared with healthy controls. This evidence concerns the gene GNG4 and age-related macular degeneration.