Among the DEGs, the CCL3, ACKR4, CCL19, CCL2, CXCL10, PPBP, CXCL9, CCL13, CCR1, CCL21, ACKR3, CXCL16, CCR5, CCL4, and CXCR6 (chemokine signaling pathway genes); C5AR1, CFH, C1R, C5AR2, CFD, C1QB, C1QC, CD59, CFP, C3AR1, C3, CR1, C1QA, and C1S (complement cascade pathway genes); and cytokine signaling pathway genes were identified as potential novel regulators of AMD. Here, C3 is linked to age-related macular degeneration.