PDCD1 and metastatic melanoma: At the time of this publication, results from the pivotal phase 3 ECHO-301/KEYNOTE-252 trial (NCT02752074) demonstrated that the combination of epacadostat 100 mg BID and pembrolizumab (anti–PD-1 inhibitor) 200 mg Q3W failed to reach the primary endpoint of improved PFS compared with pembrolizumab monotherapy in patients with unresectable/metastatic melanoma [30].