In a multivariable model (Model 1, Table 3) adjusting for age, sex, hypertension, smoking status, total cholesterol levels, blood triglycerides, BMI, blood glucose, HbA1c levels, pro-BNP, prevalent IHD and prevalent HF, only A, RWT and LV concentric geometry remained independent predictors of DM (Table 3). The gene discussed is NPPB; the disease is myocardial ischemia.