The presence of proteinase-3 31 IU/ml (Reference Value: reagent if > 3 IU/ml), cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) was verified: reactive 1:80, with renal biopsy (Figs. 1, 2 and 3) compatible with rapidly progressive glomerulonephritis (RPGN), while immunofluorescence showed granular deposits in the capillary loops of C3c (one cross) and fibrinogen (one cross). Here, PRTN3 is linked to rapidly progressive glomerulonephritis.