To determine whether cognitive deficits are correlated with Aβ-related brain pathology, we immunostained coronal brain sections from AppNL-G-F/NL-G-F, AppNL/NL and WT mice with the anti-Aβ antibody 82E1, anti-Iba1 antibody as a microglial marker, and anti-GFAP antibody as an astrocytic marker. Here, GFAP is linked to Cognitive impairment.