Development of higher quality data will further help find the best combinations of EBRT with bisphosphonates, radiopharmaceuticals, and novel biological agents reducing formation/activity of osteoclasts and bone resorption, like monoclonal antibody directed against RANKL—Receptor Activator for Nuclear Factor κ B Ligand (e.g., denosumab or novel agents, like JMT103) [171,172] or reducing cancer-induced bone osteolysis c-src inhibitors (dasatinib, bosutinib) [173]. Here, TNFSF11 is linked to cancer.