Additionally, Beclin-1 acts as a scaffold for the structure of the phosphatidylinositol 3 kinase (PI3K) complex and its levels are dysregulated in advanced stage tumors, as revealed in breast cancer, lung cancer and lymphoma, whereas conflicting data between favorable and poor prognostic values have been shown in colorectal cancer [28,30]. Here, BECN1 is linked to breast carcinoma.