The androgen-regulated glycosylation enzymes in prostate cancer include: (i) ST6GalNac1, which synthesises the cancer-associated sTn antigen, (ii) GCNT1, which is linked to the synthesis of sLeX, (iii) GalNAc transferase 7 (GALNT7), which is part of a gene signature associated with androgen receptor splice variant-7 (AR-V7), and (iv) the HBP enzyme UAP1, which is highly overexpressed in prostate cancer [57,60,88,132,138]. The gene discussed is UAP1; the disease is Familial prostate cancer.