By the analysis of four types of DNA methylation, four coding and nine non-coding RNAs, 27 peptides, and 13 glycans (in a cohort of 158 radical prostatectomy patients), combined with clinical parameters, it was possible to effectively distinguish indolent and aggressive prostate cancer with area under the ROC curve (AUC) = 0.91 (age, PSA level, Gleason score, and DRE gave an AUC of 0.67). The gene discussed is KLK3; the disease is prostate cancer.