Oxidized lipids such as oxidized phospholipids and oxidized lipoproteins (e.g., oxidized LDL) have been reported in drusen, which can act as a trigger for proinflammatory events, including complement activation, in the pathogenesis of AMD [4,5,6] Additionally, genome-wide association studies have demonstrated that genetic variants in lipid metabolism and transport genes, including hepatic lipase (LIPC), cholesterol ester transferase (CETP), apolipoprotein E (APOE) and ABC binding cassettes A1 (ABCA1), are associated with an increased risk of AMD [7,8,9]. Here, APOE is linked to age-related macular degeneration.