Tea is widely consumed in both Western and Asian countries and several mechanisms have been proposed for its anti-tumor effect, including its inhibition of c-Jun and ERK1/2 in lung cancer, phospho-Akt and nuclear β-catenin levels in colon cancer, and IGF/IGF-1R axis in colon and prostate cancer [27]. Here, MAPK3 is linked to malignant colon neoplasm.