Finally, in similar fashion to TRPV3, TRPV4, and TRPA1, the role of TRPC3 (~70 pS, PCa/PNa ~1.5:1; [105]) was thoroughly characterized for its coupling to SKCa/IKCa channels in mouse cerebral arteries [71] and rat mesenteric arteries [106] using a selective antagonist as the pyrazole compound Pyr3. The gene discussed is TRPA1; the disease is posterior cortical atrophy.