TRPC6 and posterior cortical atrophy: Whereas TRPC1-containing channels are relatively low conductance (~16 pS) and non-selective (PCa/PNa ~1:1; [85]), TRPC6 (~35 pS, PCa/PNa ~5:1; [86]) or TRPV4 (~90 pS, PCa/PNa ~6:1; [87]) channels are examples of high conductance, dominant for mediating Ca2+ (vs. Na+) influx.