Hyperosmotic stress has been associated with metabolic and cardiovascular diseases, which are probably related to the AVP response that also stimulates adrenocorticotropic hormone and cortisol release [2,7,18], and with chronic kidney disease, and a heightened inflammatory response [6], which play a role in carcinogenesis [19], muscle wasting, and aging [20]. This evidence concerns the gene POMC and cardiovascular disorder.