Accordingly, ubiquitin binding has been proven important in coupling ubiquitination with the control of protein–protein interaction, nuclear localization, degradation, and immune response [14,15,16], including extracellular signaling, such as the CXC chemokine receptor 4 (CXCR4) pathway to control apoptosis, immune responses or cancer progression [17,18,19]. This evidence concerns the gene UBB and cancer.