For example, the coexistence of beta-thalassemia and alpha-thalassemia and an increase in Hb F production.[3,4] Presently, red blood cell transfusion requirements have been used to classify the patients with thalassemia into 2 major groups that include 1) transfusion-dependent thalassemia (TDT), and 2) non-transfusion-dependent thalassemia (NTDT). Here, GSTM1 is linked to thalassemia.